UCSF - Clinical Pharmacy - Guglielmo, B. Joseph, Pharm.D.

Faculty & Staff

Guglielmo, B. Joseph, Pharm.D.

Current Title(s):
- Chair, Department of Clinical Pharmacy
- Professor of Clinical Pharmacy
- Thomas A. Oliver Chair in Clinical Pharmacy
First Year on UCSF Faculty: 1979
Education:
- Bachelor of Science, Biology, University of Santa Clara, 1973
- Pharm.D., University of Southern California, 1978
- Resident in Pharmacy, University of California, San Francisco, 1978-79
Licensure:
- Licentiate in Pharmacy, California, 1978
Specialty:
- Evidence-Based Pharmacotherapy
- Infectious Diseases

University of California, San Francisco, School of Pharmacy C-152, Box 0622, 521 Parnassus Avenue, San Francisco, CA 94143-0622
Phone: (415) 476-2354, Fax: (415) 476-6632, Email: guglielmoj@pharmacy.ucsf.edu

Professional Biography
B. Joseph Guglielmo, Pharm.D. is Professor and Chair in the Department of Clinical Pharmacy, School of Pharmacy at the University of California San Francisco. He also serves as Associate Director of Pharmaceutical Services at the UCSF Medical Center. Prior to his chairship, he was Vice Chair of Scholarship for the Department. His primary research interests involve the safe, effective, and appropriate use of antimicrobials, as well as the pharmacoepidemiology and pharmacokinetics of anti-infective agents. Dr. Guglielmo developed the Medical Center Antimicrobial Management Program in the 1980s and has mentored infectious diseases specialty residents and fellows continuously since 1986. He serves as long-term editor of Applied Therapeutics: The Clinical Use of Drugs and the Handbook for Applied Therapeutics.

Selected Peer-reviewed Publications

ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery. Expert Panel: Bosso JA, Ebert SC, Flaherty JF, Guglielmo BJ, Nicolau DP, Plaisance K, DiPiro JT, Danziger LH. Am J Health Syst Pharm 1999; 56: 1839-88.
Pharmacy-based intervention to reduce antibiotic use for acute bronchitis. D.E. Hickman, M.R. Stebbins, J.R. Hanak, B.J. Guglielmo. Ann Pharmacother 2003; 37: 187-81.
Experience with Selective Reporting of Antimicrobial Susceptibility Test Results and Physician Prescribing Patterns. B.A. Brodowy, B.J. Guglielmo, Mary K. York, E.T. Herfindal, and G.F. Brooks. Am. J. Hosp. Pharm. 46, 1816-1818 (1989).
Pharmacist-Managed Drug Therapy in California Hospitals. B.J. Guglielmo, B. Schweigert, and D.T. Kishi. Am. J. Hosp. Pharm. 46, 1366-1369 (1989).
Restricted access to automated dispensing machines for surgical prophylaxis. K. Botwin, J. Chan, R. Jacobs, B.J. Guglielmo. Am J Health Syst Pharm 2001; 58: 797-9.
Characteristics of antimicrobial overrides associated with automated dispensing machines. E. Oren, L.P. Griffiths, B.J.Guglielmo. Am J Health Syst Pharm 2002; 59: 1445-1448.
Treatment of Funguria. A. Wong-Beringer, R.A. Jacobs, B.J. Guglielmo. JAMA 267, 2780-2785 (1992).
Lipid formulations of amphotericin B: clinical efficacy and toxicities. A Wong-Beringer, R.A. Jacobs, B.J. Guglielmo. Clin Infect Dis 27: 603-18 (1998).
Antibiotic Prophylaxis in Cesarean Section. M. Glick and B.J. Guglielmo. DICP Ann. Pharmacother. 24, 841-846 (1990).
In vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri. F.L. Schuster, B. J. Guglielmo, G.S.Visvesvara. Journal of Eukaryotic Microbiology 2006; 53: 121-26.
Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model. E.J. Ernst, S. Hashimoto, J. Guglielmo, T. Sawa, J-F Pittet, H. Kropp, J.J. Jackson, J.P. Wiener-Kronish. Antimicrob Agents Chemother 1999; 43: 2389-94.
Antimicrobial drug prescribing for pneumonia in primary care. C. MacDougall, B.J. Guglielmo, J Maselli, R. Gonzales. Emerg Infect Dis 2005; 11: 380-384.
Comparative Pharmacokinetics of Low- and High-Dose Ticarcillin. B.J. Guglielmo, J.F. Flaherty, R. Batman, S.L. Barriere, and J.G. Gambertoglio. Antimicrob. Ag. Chemother. 30, 359-360 (1986).
Antimicrobial Therapy: Cost-benefit Considerations. B.J. Guglielmo and G.F. Brooks. Drugs 38, 473-480 (1989).
Prevention of adverse antimicrobial events in hospitalized patients using an antimicrobial review program. B.J. Guglielmo, R.C. Corelli, J.F. Flaherty, A.D. Luber, R.A.Jacobs. West J Med 1999 171: 159-62.
In vivo effect of I’m-YunityTM on hepatic cytochrome P450 3A4. J.P. Nicandro, C. Tsourounis, L.Frassetto, B.J. Guglielmo. J Herb Pharmacother 2006 (in press)
Pharmacokinetics of quinacrine in the treatment of prion disease. L Yung, Y. Huang, P. Lessard, G. Legname, E.T. Lin, M. Baldwin, S.B. Prusiner, C. Ryou, B.J. Guglielmo. BMC Infectious Diseases 2004; 4: 53.
Nosocomial Funguria: Resultant Morbidity and Therapeutic Intervention. A. Wong-Beringer, R.A. Jacobs, B.J. Guglielmo. Clin. Infect. Dis. 17: 1066-7 (1993).
Medication Usage Patterns in Patients with Human Immunodeficiency Virus Infection: A Comparison of Patient Reported Medication Usage with Medical Chart Review. R.L. Corelli, B.J. Guglielmo, J.E. Kapusnik-Uner, J.R. McMaster, and R.M. Greenblatt. DICP Ann. Pharmacother. 25, 1374-1377 (1991).
Effect of Surgical Blood Loss and Volume Replacement on Antibiotic Pharmacokinetics. D. Sue, T.A. Salazar, K. Turley, and B.J. Guglielmo. Ann. Thor. Surg. 47, 857-859 (1989).
Aerosolization of Imipenem/cilastatin Prevents Pseudomonas-induced lung injury. S. Hashimoto, E. Wolfe, B. Guglielmo, R. Shanks, J. Sundelof, J. Pittet, E. Thomas, J. Weiner-Kronish J Antimicrob Chemotherapy 38: 809-18 (1996)
Gram-negative Sepsis, the Sepsis Syndrome, and the Role of Antiendotoxin Monoclonal Antibodies. S.L. Barriere, B.J. Guglielmo. Clin. Pharm. 11, 223-235 (1992).
Comparison of Antibiotic Activity Using Serum Bactericidal Activity Over Time. B.J. Guglielmo and L.C. Rodondi. Antimicrob. Agents Chemother. 32 , 1511-1514 (1988).
Assessing Exposures of Health-care Personnel to Aerosols of Ribavirin-California. R.J. Harrison, J. Bellows, D. Rempel, L. Rudolph, K. Kizer, A. Jin, B.J. Guglielmo, and B.B. Bernard. Morbidity and Mortality Weekly Reports 37, 560-562 (1988).
Microbiology and Antibiotics in Infectious Abdominal Emergencies. In Emergency Medicine Clinics of North America. J. Tam and B.J. Guglielmo 7, 611-629 (1989).
Impact of a piperacillin-tazobactam shortage upon antimicrobial prescribing and the rate of vancomycin-resistant enterococcus and Clostridium difficile infection. M. Mendez, L. Gibbs, R. A. Jacobs, C. E. McCulloch, L. Winston, B. J. Guglielmo. Pharmacotherapy 2006; 26: 61-7.
Culture and allergy history do not influence fluoroquinolone use in the treatment of moderate-to-severe community acquired pneumonia. N.N. Chang, C.K Murray, P.M. Houck, D.W. Bratzler, C. Greenway, B.J. Guglielmo. Pharmacotherapy 2005; 25: 59-66.
Influence of Timing of Antibiotic Administration on Tissue Concentration During Surgery. A. Wong-Beringer, R.L Corelli, T.R. Shrock, B.J. Guglielmo. Am J Surg 56: 379-381 (1995).
Risk factors for amphotericin B-induced nephrotoxicity. A.D. Luber, L. Maa, M. Lam, B.J. Guglielmo. J Antimicrob Chemother 43: 267-71(1999)
The evolution of an antimicrobial review system at a university teaching hospital. A. D. Luber, R. C. Corelli, J. F. Flaherty, K.A. Kostiuk, M.D. Robinson, B.J. Guglielmo. J Infect Dis Pharmacother 2: 65-90 (1996).
Antibiotic Prophylaxis in Surgical Procedures. A Critical Analysis of the Literature. B.J. Guglielmo, D.C. Hohn, P.J. Koo, T.K. Hunt, R.C. Sweet, and J.E. Conte, Jr. Arch. Surg. 118, 943-955 (1983).
Ceftizoxime Versus Vancomycin and Gentamicin in Neurosurgical Prophylaxis: A Randomized, Prospective, Blinded Clinical Study. V.G. Pons, S.L. Denlinger, B.J. Guglielmo, J. Octavio, J. Flaherty, C.B. Wilson. Neurosurg. 33: 416 (1993).
Pharmacokinetics and pharmacodynamics of ceftizoxime in abscess fluid. B. J. Guglielmo, K. A. Kostiuk, V. G. Pons. J Antimicrob Chemother 39: 437-8 (1997).
Pharmacokinetics of valacyclovir. C. MacDougall, B.J. Guglielmo. J Antimicrob Chemother 2004; 53: 899-901.
ASHP Therapeutic Guidelines for Nonsurgical Antimicrobial Prophylaxis. Expert Panel: Bosso JA, Ebert SC, Flaherty JF, Guglielmo BJ, Nicolau DP, Plaisance K, DiPiro JT, Danziger LH. Am J Health Syst Pharm 1999; 56: 1201-50.
Dose-response effect of tetracyclines on cerebral matrix mealloproteinase-9 after vascular endothelial growth factor hyperstimulation. Lee, Chanhung Z., Yao, Jianhua S., Huang, Yong, Zhai, Wenwu, Liu, Weizhong, Guglielmo, B. Joseph, Lin, Emil, Yang, Guo-Yuan, Young, William L. Journal of Cerebral Blood Flow & Metabolism 2006; 26: 1157-64
What is the Clinical Role of Aerosolized Ribavirin? M.F. Hebert and B.J. Guglielmo. DICP Ann. Pharmacother. 24, 735-738 (1990).
Quinacrine is Mainly Metabolized to Mono-Desethyl Quinacrine by CYP3A4/5 and P-glycoprotein Limits its Brain Accumulation . Yong Huang, Hideaki Okochi, Barnaby C. H. May, Giuseppe Legname, Stanley B. Prusiner, Leslie Z. Benet, B. Joseph Guglielmo, Emil T. Lin. Drug Metabolism and Disposition 2006; 34: 1136-44
Effect of Protein Binding on Serum Bactericidal Activities of Ceftazidime and Cefoperazone in Healthy Volunteers. Y.W.F. Lam, M.H. Duroux, J.G. Gambertoglio, S.L. Barriere, and B.J. Guglielmo. Antimicrob. Agents Chemother. 32, 298-302 (1988).
Failure of Intravenous Vancomycin and Intravenous Metronidazole to Prevent or Treat Antibiotic-Associated Pseudomembranous Colitis. S. Oliva, B.J. Guglielmo, V.G. Pons, and R.A. Jacobs. J. Infec. Dis. 159, 1154-1155 (1989).
Altered Pharmacokinetics of Antibiotics During Vascular Surgery. B.J. Guglielmo, T.A. Salazar, L.C. Rodondi, M. Carver, J. Goldstone, and R.J. Stoney. Am. J. Surg. 157, 410-412 (1989).
Comparison of the Pharmacokinetics of Once-daily Versus Thrice-daily Tobramycin in Cystic Fibrosis Patients. B.J. Guglielmo, L. A. Quan, M.S. Stulbarg. J Antimicrob Chemother 37: 1040-1042 (1996).
Practical Strategies for the Appropriate Use of Antimicrobials. B.J. Guglielmo. Pharmacy World & Science 17: 96-102 (1995).
Compliance in two medical centers with criteria for use of caspofungin and lipid-based amphotericin B. A.N. Bower, H.M. Tang, B.J. Guglielmo. Am J Health Syst Pharm 2004; 61: 915-920.
Comparative Pharmacokinetics and Serum Inhibitory Activity of Clindamycin in Different Dosing Regimens. J.F. Flaherty, L.C. Rodondi, B.J. Guglielmo, J.C. Fleishaker, R.J. Townsend, and J.G. Gambertoglio. Antimicrob. Agents Chemother. 32, 1825-1829 (1988).
Home Antibiotic Therapy for Streptococcal Endocarditis: A Call for a Controlled Trial. J.M. Colford, R.L. Corelli, J.W. Ganz, B.J. Guglielmo, R.A. Jacobs. Am. J. Med. 94, 111-112 (1992).
Pharmacological Advances in the Treatment of Invasive Candidiasis. Daniel Deck, B. Joseph Guglielmo. Expert Rev Infect Dis 2006; 4: 137-49.
Impact of emerging technologies on medication errors and adverse drug events. E. Oren, E. Shaffer, B.J. Guglielmo Am J Health Syst Pharm 2003; 60: 1447-58.
Pharmacokinetics of Cefoperazone and Tobramycin Alone and in Combination. B.J. Guglielmo, J.F. Flaherty, T.M. Woods, G. LaFollette, and J.G. Gambertoglio. Antimicrob. Ag. Chemother. 31, 264-266 (1987).
Aerosolized amphotericin B in prophylaxis of pulmonary aspergillosis. C Tsourounis, B.J. Guglielmo Ann Pharmacother 30: 1175-1176 (1996)
Ceftriaxone treatment of staphylococcal osteomyelitis. B. J. Guglielmo, A.D. Luber, D. Paletta, R.A. Jacobs. Clin Infect Dis 2000; 30: 205-7.
Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor. D.D. Phan, P. Chin-Hong, E.T. Lin, P. Anderle, W. Sadee, B.J Guglielmo. Antimicrob Agents Chemother 2003; 47: 2351-53.
Antimicrobial therapy of gram-negative bacteremia at two university-affiliated medical centers. L. R. Graff, K. K. Franklin, L. Witt, N. Cohen, R. A. Jacobs, L. Tompkins, B. J. Guglielmo. Am J Med 2002; 112: 204-211.
Antimicrobial selection for hospitalized patients with presumed community-acquired pneumonia: A survey of non-teaching US community hospitals. V. Dudas, A. Hopefl, R. Jacobs, B. J. Guglielmo. Ann Pharmacother 2000; 34: 446-51.
The New Macrolides: Azithromycin and Clarithromycin. M. Kanatani,B.J. Guglielmo. West. J. Med. 160: 31-37 (1994).
Management of Funguria. B.J. Guglielmo, M.L. Stoller, R.A. Jacobs. Intern. J. Antimicrob. Agents 3: 10-18 (1994).
Monoclonal Therapy for Bacteremic and Septic Patients. B.J. Guglielmo, J.P. Wiener-Kronish. West J. Med. 157, 174 (1992).
Risk factors for community-acquired ciprofloxacin-resistant Escherichia coli urinary tract infection. K.M. Killgore, K.L. March, B.J. Guglielmo. Ann Pharmacother 2004; 38: 1148-52.
Systemic Absorption of Oral Fluconazole After Gastrointestinal Resection. L. A. Joe, R.A. Jacobs, B.J. Guglielmo. J Antimicrob Chemother 33: 1070 (1994).
Penetration of Fluconazole into Abscess Fluid. K.A. Kostiuk, V.G. Pons, B.J. Guglielmo. J Antimicrob Chemother 34: 603-604 (1994).
CSF Penetration of Amphotericin B in AIDS Patients With Cryptococcal Meningitis. B. Dugoni, B.J. Guglielmo, and H. Hollander. Clin. Pharm. 8, 220-221 (1988).
Impact of a restriction policy for intravenous fluconazole on patient outcomes. J.S. Burkiewicz, K.A. Kostiuk, R.A.Jacobs, B.J. Guglielmo. Ann Pharmacother 2001; 35: 9-13.
Iodine Toxicity in a Patient Treated by Continuous Povidone-Iodine Mediastinal Irrigation. P.L. Glick, B.J. Guglielmo, R.F. Tranbaugh, and K. Turley. Ann. Thorac. Surg. 39, 478-480 (1985).
Antifungal prophylaxis in chemotherapy-associated neutropenia : comparative costs and patient outcomes. Reidel, A, Yuen C, Inciardi J, Chau LS, Martin, T, Guglielmo BJ. BMC Infectious Diseases (Submitted 2006).
Continuous quality improvement with vancomycin prescribing: impact upon appropriateness of use and prevalence of vancomycin resistant enterococci. B. J. Guglielmo, V. Dudas, I. Maewal, R. Young, A. Hilts, M. Villmann, L. Gibbs, M. Gropper, R. Jacobs. Joint Commission Journal Health and Safety 2005; 31: 469-475.
Immune Globulin Therapy in Allogeneic Bone Marrow Transplant: A Critical Review. B.J. Guglielmo, A. Wong-Beringer, C. A. Linker. Bone Marr. Trans. 13: 499-510 (1994).
Mediastinal Absorption of Povidone Iodine in Dogs. P. Glick, B.J. Guglielmo, M.E. Winter, W. Finkbeiner, and K. Turley. J. Surg. Res. 49, 428-434 (1990).